Quote:
Originally Posted by docicu3
Doug
In the human world we "overshoot" coumadin or warfarin doses all the time which is easily treated by Vit K or time, often the problem isn't the drug but whatever else is eaten with the meal which can either shorten or lengthen the half life of the drug since they all work by interfering with Vit K metabolism or the liver dependent coagulation factors.
Vitamin K is used in the body to form bones but also plays an important role in blood clotting. Coumadin works by interfering with the liver synthesis of vitamin K-dependent clotting factors. Vit K decreases the amount of blood clots formed in the body the opposite of what your drugs in the article do.
In humans we use these meds to stop clotting for a bunch of reasons such as stroke prevention or avoiding clot associated with abnormal heart rythmns but yes these are the same class and effect of drugs.
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Would diphacinone interfere with the liver as well? TAP had a liver issue going with a few horses a couple years ago that a cause was never really determined, if I remember.
This is from the studyon E X T O X N E T. Interesting that it would be fed to animals to keep bats away...
"Fate in humans and animals: Rats eliminated 70% of the administered oral dose via the feces and 10% in the urine within 8 days [172]. A similar pattern of elimination occurred in mice [172]. Animal studies indicate that little metabolism takes place, and that diphacinone which is not eliminated may concentrate to varying degrees in the liver, kidneys, and lungs [8,172]. The half-life of diphacinone in humans is 15 to 20 days [8]. It was determined that cattle dosed with the compound as an anti-bat measure were safe to use for dairy and/or meat production [8]."