[Riot]

Anyone can poke around at www.ncbi.nlm.nih.gov

Use EIPH and race horse as your search terms

I found these with EIPH furosemide speed as the search terms

J Am Vet Med Assoc. 1999 Sep 1;215(5):670-5.

Effect of furosemide on performance of Thoroughbreds racing in the United States and Canada.

Gross DK, Morley PS, Hinchcliff KW, Wittum TE.
Source

Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA.
Abstract

OBJECTIVE: To determine the effect of furosemide on performance of Thoroughbreds racing on dirt surfaces at tracks in the United States and Canada.

DESIGN: Cross-sectional study.

ANIMALS: All Thoroughbreds (n = 22,589) that finished a race on dirt surfaces at tracks in the United States and Canada between June 28 and July 13, 1997 in jurisdictions that allowed the use of furosemide.

PROCEDURE: Race records were analyzed by use of multivariable ANOVA procedures and logistic regression analyses to determine the effect of furosemide on estimated 6-furlong race time, estimated racing speed, race earnings, and finish position. Principal component analysis was used to create orthogonal scores from multiple collinear variables for inclusion in the models.

RESULTS: Furosemide was administered to 16,761 (74.2%) horses. Horses that received furosemide raced faster, earned more money, and were more likely to win or finish in the top 3 positions than horses that did not. The magnitude of the effect of furosemide on estimated 6-furlong race time varied with sex, with the greatest effect in males.

When comparing horses of the same sex, horses receiving furosemide had an estimated 6-furlong race time that ranged from 0.56 +/- 0.04 seconds (least-squares mean +/- SE) to 1.09 +/- 0.07 seconds less than that for horses not receiving furosemide, a difference equivalent to 3 to 5.5 lengths.

CONCLUSIONS AND CLINICAL RELEVANCE:

Because of the pervasive use of furosemide and its apparent association with superior performance in Thoroughbred racehorses, further consideration of the use of furosemide and investigation of its effects in horses is warranted.

http://www.ncbi.nlm.nih.gov/pubmed/10476714

Am J Vet Res. 1990 May;51(5):772-8.

Effects of furosemide on the racing times of Thoroughbreds.

Sweeney CR, Soma LR, Maxson AD, Thompson JE, Holcombe SJ, Spencer PA.
Source

Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348.
Abstract

The effects of furosemide on the racing times of 79 horses without exercise-induced pulmonary hemorrhage (EIPH) and 52 horses with EIPH were investigated.

Racing times were adjusted to 1-mile equivalent racing times by 2 speed handicapping methods, and analysis of covariance was used to adjust actual racing times by winning time and distance for each race.

All 3 methods of determining racing time indicated that geldings without EIPH had significantly faster racing times (P less than 0.05) when given furosemide before racing than when furosemide was not given before racing.

Females and colts without EIPH were determined to have faster racing times when furosemide was given before racing, but the difference was not significant.

Geldings with EIPH had significantly faster racing times (P = 0.0231) when given furosemide before racing, as determined by one of the speed handicapping methods.

There was a strong correlation (range 0.9314 to 0.9751) between the 1-mile equivalent racing times, as determined by the 2 speed handicapping methods for horses with and without EIPH.

Furosemide failed to prevent the development of EIPH in many horses that were previously considered to be EIPH-negative.

When given furosemide, 62 (25.3%) of 235 EIPH-negative horses were EIPH-positive after racing.

Furosemide had questionable efficacy for prevention of EIPH in known EIPH-positive horses.

Thirty-two (61.5%) of 52 EIPH-positive horses given furosemide before a race remained EIPH-positive after that race.

http://www.ncbi.nlm.nih.gov/pubmed/2337276

Am J Vet Res. 1980 Aug;41(8):1183-9.

Effects of furosemide on cardiovascular function and performance when given prior to simulated races: a double-blind study.

Milne DW, Gabel AA, Muir WW, Skarda RT, Hamlin RL, Pipers FS.
Abstract

In a double-blind study under simulated racing conditions, six Standardbred horses, which had been trained for 12 weeks, were given 1 mg of furosemide/kg of body weight or saline solution IV 15 minutes before the first of two warm-up workouts (1.6 km at 60-minute intervals).

Sixty minutes later, 135 minutes after drug or placebo injection, these horses were driven 1.6 km at maximum speed.

Heart rate, respiratory rate, cardiac output, pulmonary trunk pressure, body temperature, PCV, arterial oxygen, and plasma lactic acid were recorded during and after the first warm-up workout and after a simulated race (1.6 km).

Values increased compared with values determined at rest whether saline solution or furosemide was given.

There were decreases in arterial CO2 and pH. When furosemide was given, the pulmonary trunk pressure was significantly lower (P < 0.05) during the first warm-up workout (1.6 km). There were no significant differences in the other values.

The average times of the simulated races were not significantly (P < 0.05) different after the use of furosemide compared with average times after use of saline solution.

http://www.ncbi.nlm.nih.gov/pubmed/6778267